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KMID : 0385219980080020027
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Korean Journal of Gerontology
1998 Volume.8 No. 2 p.27 ~ p.34
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Modulation of DHEA-Induced Peroxisomal Proliferation by Amino Acid Supplementation in Rat Liver
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Kwak Chung-Shil
Park Jun-Eui
Oh Se-In
Park Sang-Cheol
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Abstract
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DHEA(dehydroepiandrosterone) is popularized recently for its variety of biofunctions. However, the rodent data that it caused hepatomegaly with peroxisomal proliferation raised a caution for using it. In our experiment, we have intended to modulate the DHEA-induced peroxisomal proliferation through a regulation of cellular redox potential by supplementing amino acids such as aspartate and glutamate. Sprague-Dawley female rats were treated with either DHEA alone, DHEA plus aspartate or DHEA plus glutamate for one week. DHEA treatment caused an increase of liver weight with a concomitant decrease of body weight. Glutamate but not aspartate supplementation to DHEA treatment significantly activated the palmitoyl-coA oxidase and cytochrome P450 4A1, all of which generate oxygen radical. These results showed that imbalance between fatty acyl-coA oxidase and catalase could be aggravated by glutamate but ameliorated by aspartate supplementation to DHEA treatment. From these results, it is suggested that DHEA-induced hepatotoxicity, especially peroxisomal proliferation may be modulated by a simple supplementation of amino acid such as glutamate or aspartate.
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KEYWORD
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Dehydroepiandrosterone, Peroxisomal proliferation, Fatty acyl-coA oxidase, Cytochrome P450 4A1, Catalase
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